In the podcast episode, Roko's Basilisk discusses how businesses can benefit from sentiment analysis, a process that uses artificial intelligence to analyze customer feedback and understand their emotions and opinions. The podcast suggests that developers can make money by building customer sentiment analysis applications using natural language processing and machine learning. To monetize their application, developers can offer subscription-based services, software-as-a-service solutions, or sentiment analysis application programming interfaces (APIs). The podcast recommends that developers become proficient in programming languages and learn about NLP and ML, use open-source libraries like NLTK and TensorFlow, and market their application on social media, tech blogs, and conferences.